Neural Regeneration Research

REVIEW
Year
: 2021  |  Volume : 16  |  Issue : 2  |  Page : 214--217

Therapeutic potential of neuromodulation for demyelinating diseases


Elliot H Choi1, Chioma Nwakalor2, Nolan J Brown4, Joonho Lee3, Michael Y Oh5, In Hong Yang2 
1 Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH; Department of Ophthalmology, Gavin Herbert Eye Institute, School of Medicine, University of California; Department of Neurological Surgery, University of California, Irvine, CA, USA
2 Department of Mechanical Engineering and Engineering Science, Center for Biomedical Engineering and Science, University of North Carolina at Charlotte, Charlotte, NC, USA
3 University of Rochester School of Medicine and Dentistry, Rochester, NY, USA

Correspondence Address:
Elliot H Choi
Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH; Department of Ophthalmology, Gavin Herbert Eye Institute, School of Medicine, University of California; Department of Neurological Surgery, University of California, Irvine, CA
USA
In Hong Yang
Department of Mechanical Engineering and Engineering Science, Center for Biomedical Engineering and Science, University of North Carolina at Charlotte, Charlotte, NC
USA

Neuromodulation represents a cutting edge class of both invasive and non-invasive therapeutic methods which alter the activity of neurons. Currently, several different techniques have been developed - or are currently being investigated – to treat a wide variety of neurological and neuropsychiatric disorders. Recently, in vivo and in vitro studies have revealed that neuromodulation can also induce myelination, meaning that it could hold potential as a therapy for various demyelinating diseases including multiple sclerosis and progressive multifocal leukencepalopathy. These findings come on the heels of a paradigm shift in the view of myelin's role within the nervous system from a static structure to an active co-regulator of central nervous system plasticity and participant in neuron-mediated modulation. In the present review, we highlight several of the recent findings regarding the role of neural activity in altering myelination including several soluble and contact-dependent factors that seem to mediate neural activity-dependent myelination. We also highlight several considerations for neuromodulatory techniques, including the need for further research into spatiotemporal precision, dosage, and the safety and efficacy of transcranial focused ultrasound stimulation, an emerging neuromodulation technology. As the field of neuromodulation continues to evolve, it could potentially bring forth methods for the treatment of demyelinating diseases, and as such, further investigation into the mechanisms of neuron-dependent myelination as well as neuro-imaging modalities that can monitor myelination activity is warranted.


How to cite this article:
Choi EH, Nwakalor C, Brown NJ, Lee J, Oh MY, Yang IH. Therapeutic potential of neuromodulation for demyelinating diseases.Neural Regen Res 2021;16:214-217


How to cite this URL:
Choi EH, Nwakalor C, Brown NJ, Lee J, Oh MY, Yang IH. Therapeutic potential of neuromodulation for demyelinating diseases. Neural Regen Res [serial online] 2021 [cited 2020 Sep 19 ];16:214-217
Available from: http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=2;spage=214;epage=217;aulast=Choi;type=0