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  Indian J Med Microbiol
 

Figure 3: Timeline with the breakthrough discoveries about AIF. Different colors and symbols were used based on the kind of event: general biological information discovered (black diamond), new isoform discovered (blue triangle), and new protein interaction discovered (red star 8 point). AAs: Amino acids; AIF: apoptosis-inducing factor; BCL-2: B-cell lymphoma 2; CHCHD4: coiled-coil-helix-coiled-coil-helix domain-containing protein 4; CypA: cyclophilin A; Cyt c: cytochrome c; Hq: harlequin; H2AX: H2A histone family member X; HSP70: heat shock protein 70; IMS: intermembrane space; KO: knock-out; MIF: migration inhibitory factor; MIMS: mitochondrial intermembrane space; MLS: mitochondrial localization sequence; PAR: poly-ADP ribose; RIP3: receptor-interacting protein 3; ROS: reactive oxygen species; TRX: thioredoxin.

Figure 3: Timeline with the breakthrough discoveries about AIF. 
Different colors and symbols were used based on the kind of event: general biological information discovered (black diamond), new isoform discovered (blue triangle), and new protein interaction discovered (red star 8 point). AAs: Amino acids; AIF: apoptosis-inducing factor; BCL-2: B-cell lymphoma 2; CHCHD4: coiled-coil-helix-coiled-coil-helix domain-containing protein 4; CypA: cyclophilin A; Cyt c: cytochrome c; Hq: harlequin; H2AX: H2A histone family member X; HSP70: heat shock protein 70; IMS: intermembrane space; KO: knock-out; MIF: migration inhibitory factor; MIMS: mitochondrial intermembrane space; MLS: mitochondrial localization sequence; PAR: poly-ADP ribose; RIP3: receptor-interacting protein 3; ROS: reactive oxygen species; TRX: thioredoxin.