ORC ID , Alina Kazymovna Zeinalova1, Galina Andreevna Masgutova1, Alexey Andreevich Bogov Jr. 2, Cinzia Allegrucci3, Valeriia Yurievna Syromiatnikova1, Ilnur Ildusovich Salafutdinov1, Ekaterna Evgenievna Garanina1, Dina Ivanovna Andreeva1, Adilet Abdullaatovich Kadyrov4, Albert Anatolevich Rizvanov PhD 1 ORC ID , Ruslan Faridovich Masgutov5">
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REVIEW
Year : 2022  |  Volume : 17  |  Issue : 6  |  Page : 1240-1247

Application of neurotrophic and proangiogenic factors as therapy after peripheral nervous system injury


1 Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia
2 Republican Clinical Hospital, Kazan, Russia
3 Biodiscovery Institute, School of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK
4 Department of Traumatology and Orthopedics, Kazan State Medical Academy, Kazan, Russia
5 Institute of Fundamental Medicine and Biology, Kazan Federal University; Republican Clinical Hospital, Kazan, Russia

Correspondence Address:
Albert Anatolevich Rizvanov
Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan
Russia
Kamilla Faritovna Idrisova
Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan
Russia
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Source of Support: AAR was supported by state assignment 0671-2020-0058 of the Ministry of Education and Science of Russian Federation. IIS and GAM were supported by the Russian Foundation for Basic Research grant 18-54-45023 Ind_a. This work is part of Kazan Federal University Strategic Academic Leadership Program (to IIS), Conflict of Interest: None


DOI: 10.4103/1673-5374.327329

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The intrinsic ability of peripheral nerves to regenerate after injury is extremely limited, especially in case of severe injury. This often leads to poor motor function and permanent disability. Existing approaches for the treatment of injured nerves do not provide appropriate conditions to support survival and growth of nerve cells. This drawback can be compensated by the use of gene therapy and cell therapy-based drugs that locally provide an increase in the key regulators of nerve growth, including neurotrophic factors and extracellular matrix proteins. Each growth factor plays its own specific angiotrophic or neurotrophic role. Currently, growth factors are widely studied as accelerators of nerve regeneration. Particularly noteworthy is synergy between various growth factors, that is essential for both angiogenesis and neurogenesis. Fibroblast growth factor 2 and vascular endothelial growth factor are widely known for their proangiogenic effects. At the same time, fibroblast growth factor 2 and vascular endothelial growth factor stimulate neural cell growth and play an important role in neurodegenerative diseases of the peripheral nervous system. Taken together, their neurotrophic and angiogenic properties have positive effect on the regeneration process. In this review we provide an in-depth overview of the role of fibroblast growth factor 2 and vascular endothelial growth factor in the regeneration of peripheral nerves, thus demonstrating their neurotherapeutic efficacy in improving neuron survival in the peripheral nervous system.


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