ORC ID , Zhen Lyu1, Guang-Hao Zhang2, Xiao-Lin Huo2">
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RESEARCH ARTICLE
Year : 2022  |  Volume : 17  |  Issue : 6  |  Page : 1318-1323

Oscillating field stimulation promotes axon regeneration and locomotor recovery after spinal cord injury


1 Department of Spine and Spinal Cord Surgery, Beijing Bo’ai Hospital, Rehabilitation Research Center; School of Rehabilitation Medicine, Capital Medical University, Beijing, China
2 Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences; School of Electronics, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, China

Correspondence Address:
Jin-Zhu Bai
Department of Spine and Spinal Cord Surgery, Beijing Bo’ai Hospital, Rehabilitation Research Center; School of Rehabilitation Medicine, Capital Medical University, Beijing
China
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Source of Support: This study was supported by the National Natural Science Foundation of China, No. 30801222 (to JZB), Conflict of Interest: None


DOI: 10.4103/1673-5374.327349

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Oscillating field stimulation (OFS) is a potential method for treating spinal cord injury. Although it has been used in spinal cord injury (SCI) therapy in basic and clinical studies, its underlying mechanism and the correlation between its duration and nerve injury repair remain poorly understood. In this study, we established rat models of spinal cord contusion at T10 and then administered 12 weeks of OFS. The results revealed that effectively promotes the recovery of motor function required continuous OFS for more than 6 weeks. The underlying mechanism may be related to the effects of OFS on promoting axon regeneration, inhibiting astrocyte proliferation, and improving the linear arrangement of astrocytes. This study was approved by the Animal Experiments and Experimental Animal Welfare Committee of Capital Medical University (supplemental approval No. AEEI-2021-204) on July 26, 2021.


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