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Year : 2022  |  Volume : 17  |  Issue : 8  |  Page : 1640-1644

Calorie restriction or dietary restriction: how far they can protect the brain against neurodegenerative diseases?

Herz- und Diabeteszentrum NRW (HDZ NRW), Bad Oeynhausen, Germany

Correspondence Address:
Tayana Silva de Carvalho
Herz- und Diabeteszentrum NRW (HDZ NRW), Bad Oeynhausen
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Source of Support: This work was supported by the Brazilian National Council for Scientific and Technological Development (CNPq)/German Academic Exchange Service (DAAD) (290076/2014-5; to TSC), Conflict of Interest: None

DOI: 10.4103/1673-5374.332126

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Finding the correct nutritional intervention is one of the biggest challenges in treating patients with neurodegenerative diseases. In general, these patients develop strong metabolic alterations, resulting in lower treatment efficacy and higher mortality rates. However, there are still many open questions regarding the effectiveness of dietary interventions in neurodiseases. Some studies have shown that a reduction in calorie intake activates key pathways that might be important for preventing or slowing down the progression of such diseases. However, it is still unclear whether these neuroprotective effects are associated with an overall reduction in calories (hypocaloric diet) or a specific nutrient restriction (diet restriction). Therefore, here we discuss how commonly or differently hypocaloric and restricted diets modulate signaling pathways and how these changes can protect the brain against neurodegenerative diseases.

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