ORC ID , Yan-Di Yang1, Xi-Min Hu2, Wen-Ya Ning3, Lyu-Shuang Liao1, Shuang Lu1, Wen-Juan Zhao1, Qi Zhang MD 1 ORC ID , Kun Xiong MD 4 ORC ID ">
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RESEARCH ARTICLE
Year : 2022  |  Volume : 17  |  Issue : 8  |  Page : 1761-1768

Do pyroptosis, apoptosis, and necroptosis (PANoptosis) exist in cerebral ischemia? Evidence from cell and rodent studies


1 Department of Neurobiology and Human Anatomy, School of Basic Medical Science, Central South University, Changsha, Hunan Province, China
2 Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China
3 Department of Human Resources, Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China
4 Department of Neurobiology and Human Anatomy, School of Basic Medical Science, Central South University; Hunan Key Laboratory of Ophthalmology, Changsha, Hunan Province, China

Correspondence Address:
Kun Xiong
Department of Neurobiology and Human Anatomy, School of Basic Medical Science, Central South University; Hunan Key Laboratory of Ophthalmology, Changsha, Hunan Province
China
Qi Zhang
Department of Neurobiology and Human Anatomy, School of Basic Medical Science, Central South University, Changsha, Hunan Province
China
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Source of Support: The study was supported by the National Natural Science Foundation of China, Nos. 81772134 (to KX), 81971891 (to KX), 82172196 (to KX), 81571939 (to KX); the Fundamental Research Funds for the Central Universities of Central South University of China, No. 2020zzts218, (to WTY); Hunan Provincial Innovation Foundation For Postgraduate of China, Nos. CX20200116 (to WTY), CX20190139 (to LSL), Conflict of Interest: None


DOI: 10.4103/1673-5374.331539

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Some scholars have recently developed the concept of PANoptosis in the study of infectious diseases where pyroptosis, apoptosis and necroptosis act in consort in a multimeric protein complex, PANoptosome. This allows all the components of PANoptosis to be regulated simultaneously. PANoptosis provides a new way to study the regulation of cell death, in that different types of cell death may be regulated at the same time. To test whether PANoptosis exists in diseases other than infectious diseases, we chose cerebral ischemia/reperfusion injury as the research model, collected articles researching cerebral ischemia/reperfusion from three major databases, obtained the original research data from these articles by bibliometrics, data mining and other methods, then integrated and analyzed these data. We selected papers that investigated at least two of the components of PANoptosis to check its occurrence in ischemia/reperfusion. In the cell model simulating ischemic brain injury, pyroptosis, apoptosis and necroptosis occur together and this phenomenon exists widely in different passage cell lines or primary neurons. Pyroptosis, apoptosis and necroptosis also occurred in rat and mouse models of ischemia/reperfusion injury. This confirms that PANoptosis is observed in ischemic brain injury and indicates that PANoptosis can be a target in the regulation of various central nervous system diseases.


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