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Advancements in our understanding of circular and long non-coding RNAs in spinal cord injury


1 Central Laboratory, Beijing Luhe Hospital, Capital Medical University, Beijing, China
2 Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, USA
3 Central Laboratory, Beijing Luhe Hospital, Capital Medical University; Department of General Surgery, Beijing Luhe Hospital, Capital Medical University, Beijing, China

Correspondence Address:
Wei Han,
MD, PhD, Central Laboratory, Beijing Luhe Hospital, Capital Medical University; Department of General Surgery, Beijing Luhe Hospital, Capital Medical University, Beijing
China
Yu-Chuan Ding,
MD, PhD, Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI
USA
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1673-5374.335835

Spinal cord injury (SCI), either from trauma or degenerative changes, can result in severe disability and impaired quality of life. Understanding the cellular processes and molecular mechanisms that underlie SCI is imperative to identifying molecular targets for potential therapy. Recent studies have shown that non-coding RNAs, including both long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), regulate various cellular processes in SCI. In this review, we will describe the changes in lncRNA and circRNA expression that occur after SCI and how these changes may be related to SCI progression. Current evidence for the roles of lncRNAs and circRNAs in neuronal cell death and glial cell activation will also be reviewed. Finally, the possibility that lncRNAs and circRNAs are novel modulators of SCI pathogenesis will be discussed.


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