Neural Regeneration Research

REVIEW
Year
: 2022  |  Volume : 17  |  Issue : 6  |  Page : 1165--1171

The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders


Rafhanah Banu Bte Abdul Razar1, Yinghua Qu2, Saravanan Gunaseelan2, John Jia En Chua3 
1 Department of Physiology, Yong Loo Lin School of Medicine; LSI Neurobiology Programme; Institute for Health Innovation and Technology, National University of Singapore, Singapore, Singapore
2 Department of Physiology, Yong Loo Lin School of Medicine; LSI Neurobiology Programme, National University of Singapore, Singapore, Singapore
3 Department of Physiology, Yong Loo Lin School of Medicine; LSI Neurobiology Programme; Institute for Health Innovation and Technology; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore

Correspondence Address:
John Jia En Chua
Department of Physiology, Yong Loo Lin School of Medicine; LSI Neurobiology Programme; Institute for Health Innovation and Technology; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR)
Singapore

The human brain contains an estimated 100 billion neurons that must be systematically organized into functional neural circuits for it to function properly. These circuits range from short-range local signaling networks between neighboring neurons to long-range networks formed between various brain regions. Compelling converging evidence indicates that alterations in neural circuits arising from abnormalities during early neuronal development or neurodegeneration contribute significantly to the etiology of neurological disorders. Supporting this notion, efforts to identify genetic causes of these disorders have uncovered an over-representation of genes encoding proteins involved in the processes of neuronal differentiation, maturation, synaptogenesis and synaptic function. Fasciculation and elongation protein zeta-1, a Kinesin-1 adapter, has emerged as a key central player involved in many of these processes. Fasciculation and elongation protein zeta-1-dependent transport of synaptic cargoes and mitochondria is essential for neuronal development and synapse establishment. Furthermore, it acts downstream of guidance cue pathways to regulate axo-dendritic development. Significantly, perturbing its function causes abnormalities in neuronal development and synapse formation both in the brain as well as the peripheral nervous system. Mutations and deletions of the fasciculation and elongation protein zeta-1 gene are linked to neurodevelopmental disorders. Moreover, altered phosphorylation of the protein contributes to neurodegenerative disorders. Together, these findings strongly implicate the importance of fasciculation and elongation protein zeta-1 in the establishment of neuronal circuits and its maintenance.


How to cite this article:
Razar RB, Qu Y, Gunaseelan S, Chua JJ. The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders.Neural Regen Res 2022;17:1165-1171


How to cite this URL:
Razar RB, Qu Y, Gunaseelan S, Chua JJ. The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders. Neural Regen Res [serial online] 2022 [cited 2021 Dec 3 ];17:1165-1171
Available from: http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=6;spage=1165;epage=1171;aulast=Razar;type=0