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  Indian J Med Microbiol
 

Figure 1: Hv1 and Nox2 are upregulated in two independent models of spinal cord injury (SCI). (A) Schematic illustration depicts experimental design of the study by Noristani et al. (2017) showing isolation of Cx3cr1-gfp+ microglia/macrophages from the spinal cord at the epicenter of the injury following either a full transection (FT) or hemi section (HS) for RNA sequencing. (B, C) Plots show counts of Cx3cr1-gfp+ cells with Hcvn1 expression (B) or Cybb expression (C) in non-injured and at 72 hours, 1 and 2 weeks after wither FT or HS injury. The genes Hvcn1 and Cybb encodes for Hv1 channel and NOX2, respectively. *P < 0.05, **P < 0.01 and *** P < 0.001. (D, E) Schematic depicting experiment performed by Murugan et al. (2020) (D) and the results from BMS scoring (E). The total BMS scores in Hv1–/– mice measured at different time points following SCI showed faster locomotor recovery compared to age-matched controls (WT, n = 11; Hv1–/–, n = 18) (*P < 0.05, **P < 0.01, ***P < 0.001). BMS: Basso mouse scale; Hv1–/–: Hv1 knockout mice; w: week; WT: wild-type.

<b>Figure 1: Hv1 and Nox2 are upregulated in two independent models of spinal cord injury (SCI).</b>
(A) Schematic illustration depicts experimental design of the study by Noristani et al. (2017) showing isolation of Cx3cr1-gfp<sup>+</sup> microglia/macrophages from the spinal cord at the epicenter of the injury following either a full transection (FT) or hemi section (HS) for RNA sequencing. (B, C) Plots show counts of Cx3cr1-gfp<sup>+</sup> cells with Hcvn1 expression (B) or Cybb expression (C) in non-injured and at 72 hours, 1 and 2 weeks after wither FT or HS injury. The genes Hvcn1 and Cybb encodes for Hv1 channel and NOX2, respectively. *<i>P</i> < 0.05, **<i>P</i> < 0.01 and *** <i>P</i> < 0.001. (D, E) Schematic depicting experiment performed by Murugan et al. (2020) (D) and the results from BMS scoring (E). The total BMS scores in Hv1<sup>–/–</sup> mice measured at different time points following SCI showed faster locomotor recovery compared to age-matched controls (WT, <i>n</i> = 11; Hv1<sup>–/–</sup>, <i>n</i> = 18) (*<i>P</i> < 0.05, **<i>P</i> < 0.01, ***<i>P</i> < 0.001). BMS: Basso mouse scale; Hv1<sup>–/–</sup>: Hv1 knockout mice; w: week; WT: wild-type.