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  Indian J Med Microbiol
 

Figure 2: Microglial Hv1 mechanisms in SCI. Schematic figure of microglia Hv1-mediated mechanism following SCI. Cooperative function of Hv1 and NOX2 following SCI leads to excessive ROS and pro-inflammatory cytokine production, resulting in increased tissue damages. Hv1–/–: Hv1 knockout mice; NOX 2: NADPH oxidase2; ROS: reactive oxygen species; SCI: spinal cord injury.

<b>Figure 2: Microglial Hv1 mechanisms in SCI.</b>
Schematic figure of microglia Hv1-mediated mechanism following SCI. Cooperative function of Hv1 and NOX2 following SCI leads to excessive ROS and pro-inflammatory cytokine production, resulting in increased tissue damages. Hv1<sup>–/–</sup>: Hv1 knockout mice; NOX 2: NADPH oxidase2; ROS: reactive oxygen species; SCI: spinal cord injury.