Figure 1: Regulatory mechanism for the coordinated expression of myelin and nodal genes in myelinating glia. In the peripheral nervous system (PNS) (upper box), Sox10 first activates Krox20. The combination of both transcription factors then cooperatively activates myelin as well as nodal genes in Schwann cell (SC). In the central nervous system (CNS) (lower box), Myrf is the central transcription factor induced by Sox10 during oligodendrocyte (OL) differentiation. The combination of both proteins cooperates in the activation of myelin gene expression. Not yet known is their relevance for nodal gene expression in the CNS.