Figure 1: NG2 and TBX21 expression improves the ability to study normal and pathological responses of PSCs at the NMJ. (A) Co-localization between the Schwann cell marker S100-EGFP and newly discovered markers NG2 and TBX21 in PSCs could enhance isolation and analysis of various biological processes in the healthy NMJ. (B) Their role in guiding regenerating axons to reinnervate the NMJ post-injury. Specific transcription and translational changes in PSCs in response to nerve injury and axon regeneration are of particular interest. AchRs: Acetylcholine receptors; EGFP: enhanced green fluorescent protein; FACS/MACS: fluorescence/magnetic activated cell sorting; GFAP: glial-fibrillary acidic protein; GPR126: G-coupled protein receptor 126; LCMD: laser capture microdissection; NG2: neural-glial antigen-2; NMJ: neuromuscular junction; PSCs: perisynaptic Schwann cell; TBX21: T-Box transcription factor 21. Created with BioRender.com.