Figure 4: Immunohistochemical results of p-PI3K and p-Akt in the retina of mice at the age of 17 days. (A) Representative immunohistochemical images (original magnification, 400×). The arrows indicate the positive cells. (B) Statistical analysis of the integrated optical density (OD). Data are expressed as the mean ± SD (n = 15 mice per group). **P < 0.01 (Mann-Whitney U test). p-AKT: Serine/threonine kinase; OIR-C: oxygen induced retinopathy, control eye; OIR-T: oxygen induced retinopathy eye injected intravitreally with MEG3 overexpression lentivirus; p-PI3K: phosphoinositide 3-kinase.