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  Indian J Med Microbiol
 

Figure 6: Mean fluorescence intensities of various immunostained sections. Cell transplantation (hMSCs, red bars; nv-hMSCs, blue bars) affected fluorescence intensity more than treatment with mAPP96-110 (± viable/nv-hMSCs; horizontal striped bars) or APP96-110 (± viable/nv-hMSCs; diagonal striped bars). Cell transplantation significantly increased the mean fluorescence intensity of βIII tubulin (A), GFAP (E) and laminin (F), decreased SMI32 (C), S100 (D; APP96-110 + hMSCs and nv-hMSCs only) and ED1 (H), and had no effect on GAP43 (B) or Iba1 (G) fluorescence intensity. mAPP96-110 and APP96-110 significantly increased the mean fluorescence intensity of SMI32 (C), S100 (D) and laminin (F; APP96-110 only). Significance to SCI, mAPP, APP (*), SCI (σ), mAPP96-110 (π), APP96-110 (ω), hMSCs (α) and nv-hMSCs (ε); (P < 0.05, two-way analysis of variance followed by Fisher’s least significant difference test). Data are expressed as the mean ± SEM. APP96-110: Amyloid precursor protein peptide; GAP43: growth associated protein-43; GFAP: glial fibrillary acidic protein; hMSCs: human mesenchymal stromal cells; mAPP96-100: mutant amyloid precursor protein; nv: non-viable.

<b>Figure 6: Mean fluorescence intensities of various immunostained sections.</b>
Cell transplantation (hMSCs, red bars; nv-hMSCs, blue bars) affected fluorescence intensity more than treatment with mAPP96-110 (± viable/nv-hMSCs; horizontal striped bars) or APP96-110 (± viable/nv-hMSCs; diagonal striped bars). Cell transplantation significantly increased the mean fluorescence intensity of βIII tubulin (A), GFAP (E) and laminin (F), decreased SMI32 (C), S100 (D; APP96-110 + hMSCs and nv-hMSCs only) and ED1 (H), and had no effect on GAP43 (B) or Iba1 (G) fluorescence intensity. mAPP96-110 and APP96-110 significantly increased the mean fluorescence intensity of SMI32 (C), S100 (D) and laminin (F; APP96-110 only). Significance to SCI, mAPP, APP (*), SCI (σ), mAPP96-110 (π), APP96-110 (ω), hMSCs (α) and nv-hMSCs (ε); (<i>P</i> < 0.05, two-way analysis of variance followed by Fisher’s least significant difference test). Data are expressed as the mean ± SEM. APP96-110: Amyloid precursor protein peptide; GAP43: growth associated protein-43; GFAP: glial fibrillary acidic protein; hMSCs: human mesenchymal stromal cells; mAPP96-100: mutant amyloid precursor protein; nv: non-viable.